The miRNA-mRNA network suggested that the miR-766-3p/TGFBI, miR-1238-5p/ZNF652 and miR-1237-3p/SH2B3 axes may be involved in diabetic nephropathy and that most target genes have differences in DNA methylation levels between the DN group and the control group. The gene discussed is TGFBI; the disease is diabetic kidney disease.