Data mining of thousands of primary tumors corresponding to all cancer types available at The Cancer Genome Atlas (TCGA) (https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga) did not indicate the presence of TRMT5, TYW1, TYW3, TYW4 or TYW5 promoter hypermethylation events (SI Appendix, Fig. S1A and Dataset S1). The gene discussed is TYW3; the disease is cancer.