As was shown for TYW2 DNA methylation (Fig. 4B), multivariate Cox regression analysis identified low TYW2 expression as an independent predictor of shorter overall survival in early-stage colorectal cancer (HR = 4.09; 95% CI = 1.71 to 9.79; P = 0.002) compared with other patient characteristics that also have been associated with clinical outcome (SI Appendix, Fig. S13C). The gene discussed is TYW2; the disease is colorectal cancer.