To solve this enigma, we wondered about the presence of cancer-specific defects in the six enzymes, TRMT5 (20) and TYW1–5 (21, 22), that act sequentially in humans to modify the original G37 nucleotide to finally obtain the hypermodified yW in its hydroxylated (OHyW) or peroxydated (o2yW) form. The gene discussed is TRMT5; the disease is cancer.