TYW2 and colorectal carcinoma: Having demonstrated the presence of TYW2 promoter CpG island hypermethylation-associated transcriptional silencing and its role in the generation of hypomodified guanosine in tRNAPhe and ribosome frameshift-associated RNA degradation, we studied if TYW2 epigenetic loss in primary colorectal carcinoma had any impact on outcome in these patients.