SFRP2 and colorectal carcinoma: Similarly, in Lu et al.’s study [49], ORs for individual associations of methylated SFRP2, GATA4/5, NDRG4, and VIM with CRC ranged from 4.0 to 24.6, but when combined into a panel (defined as presence of at least 1 methylation among the gene promoters), the OR increased to 50.1.