In a study by Guo et al. [25], a promising marker for stage I CRC detection was identified in the promoter region of FBN1. The marker showed a 92% sensitivity at 93% specificity (OR = 154.0, 95% CI = 12.7–1875.6, p < 0.001) for detecting stage I CRC. This evidence concerns the gene FBN1 and colorectal carcinoma.