As we were able to show an interaction between p53 and tau, we also wanted to determine if tau oligomers (tauO) were part of the total tau species previously observed, as tauO have been shown to cause toxicity and cross-seed other proteins in AD [19, 20, 31, 46, 53, 64, 67, 86, 113]. This evidence concerns the gene MAPT and Alzheimer disease.