Human AD frontal cortex (Braak stage 6) and age-matched control patients (Braak stage 0–1) (Supplemental Table 1) were analyzed by immunofluorescence for total p53 and oligomers using I11, a polyclonal antibody that detects the conformation of oligomers formed by a variety of aggregation-prone proteins [55] and evaluated by confocal microscopy. Here, TP53 is linked to Alzheimer disease.