An additional objective was to analyse the effect of the diabetic milieu and of FL-926-16 on the activity of Yes-associated protein (YAP), a key downstream target of KRAS signalling required for progression of pancreatic intraepithelial neoplasias (PanINs) to invasive PaC [24, 25] and for MGO-induced tumour growth [23]. The gene discussed is KRAS; the disease is neoplasm.