Although the anti-inflammatory mechanisms through which the administration of dexmedetomidine suppresses inflammation remain to be fully elucidated, previous studies suggest that administration of dexmedetomidine decreases the levels of pro-inflammatory cytokines such as IL-6 and TNF-α in patients with sepsis [25], as well as the levels of pro-inflammatory cytokines and CRP in patients undergoing surgery while under anesthesia [9]. Here, TNF is linked to Sepsis.