PTGS2 and breast carcinoma: Of note, in line with our findings regarding the hypoxia-dependent activation of the IL-1β/COX2 signaling toward the stimulation of growth and invasion of TNBC cells, previous studies have shown that the MDA-MB-231 cells display a lipidomic profile characterized by high levels of polyunsaturated fatty acids that are known to contribute to breast cancer progression, as mentioned above [85–87].