GZMA and neoplasm: Researchers confirmed that the expression of GSDMB, but not other GSDMs, induced pyroptosis through a mechanism facilitated by granzyme A. In fact, all findings combined indicate that the mechanism of pyroptosis induction by NK cells may vary among different cell lines, suggesting that tumor cells with different molecular characteristics potentially dictate the activation of the respective GSDM-granzyme axis [30, 31, 115].