Perforin was postulated to be the only pore-forming protein used by CD8+ T cells [116], but the authors proposed that GSDMD may be a new pore-forming protein that can be harnessed by effector T cells and form pores within mammalian cells, although the mechanism by which GSDMD is delivered into tumor cells from CD8+ T cells remains unclear. Here, PRF1 is linked to neoplasm.