IL4 and early-onset autosomal dominant Alzheimer disease: Intracerebral microinjection of a mixture of IL-4 and IL-13 effectively restored spatial memory and learning abilities in C57BL/6 mice with overexpression of the amyloid-protein precursor 23 gene (AβPP23) (Alzheimer’s disease) through the increase of the IL-4 content in the hippocampus [37].