All detected PIK3CA variants have been reported previously in patients with PROS or various cancers, and could be classified as pathogenic or likely pathogenic variants in online databases including ClinVar (http://www.ncbi.nlm.nih.gov/clinvar) and COSMIC (Catalogue Of Somatic Mutations In Cancer, http://cancer.sanger.ac.uk/cosmic). The gene discussed is PIK3CA; the disease is cancer.