FTLD-PSP cases had a low burden and limited activation of all microglial phenotypes in frontotemporal regions, but other studies of FTLD-PSP have shown pronounced microgliosis in subcortical and infratentorial structures, correlating with tau burden [35, 66], and that activation detected using microglial PET occurs in subcortical but not cortical regions [67]. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.