CHEK2 and Familial prostate cancer: In addition, a report in the New England Journal of Medicine using a high-throughput, next-generation sequencing assay in prostate cancer showed the detection of genomic alteration in genes involved in homologous repair pathway BRCA2, ATM, BRCA1, PALB2, CHEK2, FANCA, and HDAC2, is associated with response to olaparib [5].