BDNF and Constipation: The result of the one clinical trial demonstrates that in women with endometriosis, treatment with melatonin (10 mg for 8 weak) compared with placebo reduced daily pain, dysmenorrhea, dysuria, dyschezia, and need to use analgesic drugs, also improved SQ, and reduced the level of brain-derived neurotropic factor (BDNF) [14].