These results drive us to suspect that these patients may harbor genetic alterations in other genes implicated in HBOC syndrome such as TP53, PTEN, ATM, NBS1, RAD50, BRIP1 and PALB2, which emphasize the need for analyzing all the genes implicated in HBOC in one workflow instead of only BRCA1/2. This evidence concerns the gene PTEN and Hereditary breast and ovarian cancer syndrome.