For high‐grade gliomas, WHO grade (HR, 4.06; 95% CI, 1.23‐13.42; P = .021), presurgery MMS (HR, 1.99; 95% CI, 1.20‐3.31; P = .008), and Ki‐67 expression (HR, 3.47; 95% CI, 1.33‐9.02; P = .011) were significantly correlated with OS. This evidence concerns the gene MKI67 and central nervous system cancer.