Whether PCK1 and PCK2 play a mechanistic role in cancer cell adaptation to the metabolic microenvironment in NSCLC metastases and whether the size of the metastases, their oxygenation status or other factors in the metastatic microenvironment influence PCK1/2 abundance, however, remains to be elucidated in future studies. This evidence concerns the gene PCK2 and non-small cell lung carcinoma.