Importantly, polyalanine-ATXN8 proteins have been observed in the cerebella of SCA8 human patients and mouse models, and a similar approach has provided evidence of a polyglutamine RAN product from the DMPK gene with expanded CAG repeats in myotonic dystrophy (Zu et al., 2011). The gene discussed is ATXN8; the disease is spinocerebellar ataxia type 8.