Although the mechanisms of the analgesic effect of ESWT are unclear, hyperstimulation of nociceptors that alters cell membrane permeability of nociceptors [34], suppression of neurotransmitter substance P, and increased local pain-inhibiting substances [35] have been suggested in musculoskeletal diseases such as plantar fasciitis, Achilles tendinopathy and gluteal tendinopathy. Here, TAC1 is linked to musculoskeletal system disorder.