We found 20 HLA alleles in the HLA-A, HLA-C, HLA-B, HLA-DRB3, HLA-DRB1, HLA-DQA1, HLA-DQB1 and HLA-DPB1 genes to be significantly associated with leprosy per se under an additive model (Table 2). This evidence concerns the gene HLA-DRB1 and leprosy.