Staining primary tumors for Bcl-2, an anti-apoptotic protein, revealed that increased Bcl-2 positivity was associated with longer survival, disease-free survival and cancer-specific survival [49]; however only a small proportion of FMT were positive for Bcl-2 in this study, and thus this marker may only be used to prognosticate a subpopulation of feline patients. This evidence concerns the gene BCL2 and cancer.