TM6SF2 and metabolic dysfunction-associated steatotic liver disease: By using genome-wide association studies, multiple NAFLD-related risk variants have been identified, among which include rs58542926 in the transmembrane 6 superfamily member 2 (TM6SF2) gene that causes a nonsynonymous glutamate-to-lysine substitution at the amino acid residue 167 (E167K) [10, 11].