TM6SF2 and metabolic dysfunction-associated steatotic liver disease: In mice, knockout or knockdown of Tm6sf2 recapitulates the human NAFLD phenotypes [10, 11, 13, 15], whereas liver-specific overexpression of TM6SF2 elevates plasma total cholesterol (TC) and LDL-C levels with, however, mixed results on hepatic TG content [10, 15].