This impairment in SC fusion may be a result of decreased expression of MyoD, myogenin, and myosin heavy chain, as reported previously (Tamilarasan et al., 2012), or could be linked to chronic inflammation associated with obesity (Arnold et al., 2007; Saclier et al., 2013). Here, MYOD1 is linked to obesity due to melanocortin 4 receptor deficiency.