The most frequent EGFR mutations found by traditional or comprehensive molecular profiling of lung adenocarcinomas include indels of exon 19 (the exon 19 deletion delE746_A750 being the most common, followed by delE746_S752insV) and the exon 21 L858R point mutation, accounting for 90% of mutations. 12. The gene discussed is EGFR; the disease is lung adenocarcinoma.