WGS analysis of leukocyte DNA from two affected individuals (Figure 1a, II.1 and II.2) confirmed the absence of UMOD and REN abnormalities, and also an absence of abnormalities within the SEC61A1 and HNF-1β genes that have been reported to be associated with FJHN. The gene discussed is SEC61A1; the disease is familial juvenile hyperuricemic nephropathy.