COL4A1 and epilepsy: One implication of PM must be that, we should, for example, seek out the mechanisms that lead a pathogenic variant segregating in a kindred to cause a mild epilepsy (eg, GEFS+, genetic epilepsy with febrile seizures+) in one individual, and a severe epilepsy (eg, Dravet syndrome) in a relative (COL4A1‐related disorder is another example).39, 40