The miR-331-3p gene is located at 12q22 and has been found to regulate the development and progression of various types of cancer cells [43–45]; in particular, miR‐331-3p contributes to cell growth regulation by targeting ERBB expression and blocks phosphatidylinositol 3-kinase (PI3K)/AKT signaling, one of the upstream pathways of JNK signaling. This evidence concerns the gene MAPK8 and cancer.