CREB1 and central nervous system cancer: The expression of HAS2-AS1 can be regulated by many transcription factors in a variety of cancers including glioma, such as CREB1 [25], hypoxia-inducible factor 1α (HIF-1α) [26], signal transducer and activator of transcription 1 (STAT1) [23] etc. However, gene expression is regulated by many factors, so it is of great significance to further explore new transcription factors to construct a complete regulatory network.