STAT3 and neoplasm: Since phenomena of EMT, chemoresistance, tumor invasion, metastasis, recurrence and CSCs are inter-related, development of multi-targeted approaches in the future may help to eradicate various CSC populations expressing CD117, CD133, Notch and targeting of EMT/CSCs pathways such as PI3K/mTOR, JAK2/STAT3, DNA methyltransferase, p53 mediated apoptosis, EGFR/Stat3, TGF- β, Notch3/ERK etc. may prove highly promising.