Jin [82] showed that activation of JAK/STAT3 pathway leads to increased tumorigenesis and metastasis ability, the transition of cancer stem cells (CSCs), and chemoresistance in cancer through the regulation of epithelial-mesenchymal transition (EMT) [82] inducing transcription factors such as Snail, Zeb1, JUNB, and Twist1 [84–86, 86]. This evidence concerns the gene ZEB1 and cancer.