In disease, tau becomes misfolded and physiochemically abnormal and accumulates as insoluble inclusions in neurons and/or glia, the neuropathologic detection of which denotes the condition as a “tauopathy.” Recent evidence has uncovered “prion‐like” cell‐to‐cell tau propagation along the neuro‐anatomic connectome and strain‐specific tau pathologic inclusions and seeding characteristics.3, 4, 5. The gene discussed is MAPT; the disease is tauopathy.