Among the myokines that have been cited in the literature as having a possible role in modulating the pathogenesis of myositis, we will address the following: interleukins (IL-6, IL-15, IL-18), chemokines (CXCL10, CCL2, CCL4, CCL5, CCL20), myostatin, follistatin, decorin, osteonectin, and insulin-like 6. The gene discussed is SPARC; the disease is myositis disease.