CD274 and neoplasm: For example, IL-1β overexpression can recruit nonspecific lymphocytes to prevent direct contact between EBV-specific cytotoxic T cells and tumor cells [52]; IFN-γ overexpression can inhibit the proliferation and activation of CTL and NK cells [53]; PD-L1 expansion can inhibit the proliferation of T cells and the release of cytokines by interacting with PD-L1 receptors on T cells, and they can also induce CTL apoptosis and promote the differentiation from CD4+ T cells into Treg cells [53].