For example, a Japanese study found that mutations of RIPK2 gene (receptor-interacting serine/threonine kinase 2) (rs16900627 minor allele genotype) increased the aggregation of inflammatory cells by changing the innate immune response of the gastric mucosa, leading to the atrophy of the gastric mucosa and increased risks of intestinal gastric cancer [69]. The gene discussed is RIPK2; the disease is gastric cancer.