TGF-β signaling, a critical factor for putting the stable atherosclerotic plaques at the risk of rupture, is affected by CAD-related miRNAs such as miR-21, miR-25, and miR-106b via the mechanism of affecting CDKN1A/p21 and BCL2L11/Bim [73–75]. The gene discussed is TGFB1; the disease is coronary artery disorder.