CD4 and tuberculosis: In this tuberculosis model, immunisation with rTB10.4 antigen + CAF05 adjuvant (potentially CD8+ T-cell response-inducing adjuvant composed of DDA/TDB/poly I: C) resulted in only CD4+ T-cell responses rather than the expected CD8+ T-cell responses, while the same antigen induced strong CD8+ T-cell responses with M. tuberculosis infection [31], suggesting that recombinant protein vaccination even with a potentially cross-presentation-activating adjuvant like CAF05 or CpG cannot always successfully induce the expected CD8+ T-cell responses.