KLK3 and posterior cortical atrophy: Recently, Loeb et al. came to a conclusion that inclusion of phi into the multivariate logistic regression model, which consisted of age, previous biopsy, PV, and tPSA, improved AUC from 0.70 to 0.75 to predict ISUP grade ≥ 2 PCa in males with negative DRE and PSA between 2 and 10 ng/mL [31].