More importantly, in this in vivo study, we not only analyzed the IL-6, TNF-α, IL-10, and TGF-β in plasma and tissues of ApoE-/- mice as in vitro experiments but also included the detection of MCP-1 and IL-1β which are implicated to be particularly important biomarkers for CAD diagnosis and mortality prediction [28, 29]. The gene discussed is APOE; the disease is coronary artery disorder.