For example, Mamoru et al. [14] used the microarray analysis to identify four toll-like receptor 4- (TLR4-) responsive miRNAs (miR-31, miR-181a, miR-16, and miR-145) in CAD and subsequent qPCR verified that their expressions were all significantly lower in the plasma of CAD patients than that in the non-CAD group. This evidence concerns the gene TLR4 and coronary artery disorder.