The hypothesis of the pathogenesis of preeclampsia is that the expression of NOS decreased and NO synthesis reduced, resulting in increased vascular bed resistance and blocked placental blood circulation, while the successful pregnancy during the first trimester depends on the favoring invasion of trophoblasts to the endometrium and the success remodeling of the uterine spiral arteries, and NO plays important roles in this process. The gene discussed is NOS1; the disease is preeclampsia.