BRAF and melanoma: According to these mutations and with the data published by The Cancer Genome Atlas (TCGA) in a complete exome sequence analysis of samples from 333 individuals with primary and metastatic melanoma, melanomas can be classified into 4 genomic groups: BRAF mutants, NRAS mutants, NF1 mutants (gene for neurofibromatosis type 1), and triple wild-type mutants.