The results presented in this study demonstrate that the association of Ramadan intermittent fasting with profound changes in lifestyle, such as altered sleeping durations and times, and changes in physical activities as well as in feeding patterns and restriction of food intake to night-time only decreased adiponectin and increased leptin, LAR, insulin, and insulin resistance in both Type 2 DM and their FDRs as well as decreased GH in both FDRs and healthy controls and increased hs-CRP in healthy controls. The gene discussed is LEP; the disease is Insulin resistance.