All the ten hub genes (CDK1, CCNB1, CCNB2, PBK, ASPM, NDC80, AURKA, TPX2, KIF2C, and CENPF) were verified to be significantly upregulated in tumor tissues from the liver of HBV-HCC patients, compared with the normal liver tissues (P < 0.01) (Figures 6(a)–6(j)). This evidence concerns the gene TPX2 and hepatocellular carcinoma.