As in the DSS-colitis model reported earlier from our laboratory (17), we noticed an increasing trend in the expression of Cox-2 (Ptgs2) in Se-D colonic tissue compared to the Se-A and Se-S mice following infection; however, the levels of 15-Pgdh, were significantly decreased on day 11 PI by 1.6 and 1.7 in Se-D colonic tissue when compared to Se-A and Se-S colonic tissues, respectively (Figures 3A–D). Here, PTGS2 is linked to colitis.