AREG and colorectal carcinoma: Furthermore, in contrast to the effect of miR-92a-3p (Hu J. L. et al., 2019), we found no difference in CRC cell proliferation or apoptosis when using normal fibroblasts, CRC-Fs or when these cells were pre-treated with TGFβ, suggesting that the AREG-mediated EV effect is independent of fibroblast activation.