(iv) Overexpression of certain enzymes such as, the fibroblast-activation protein-α (FAP-α) expressed by cancer-associated fibroblasts (CAFs) (Kalluri and Zeisberg, 2006; Tlsty and Coussens, 2006; Erez et al., 2010; Ji et al., 2013) and matrix metalloproteinases (MMPs) secreted by tumor-associated inflammatory cells in the extracellular matrix (Lu et al., 2012; Ji et al., 2013). This evidence concerns the gene FAP and neoplasm.