CDH2 and cancer: Importantly, E‐cadherin‐based AJs are significantly more stable than those established by N‐cadherin.[56] N‐cadherin is typically expressed by cells with mesenchymal phenotype such as fibroblasts and overexpressed in several types of cancer where it drives detachment from the primary tumor, invasion, and metastatization.[57] This similarity suggests that AJs established by PM‐YFP MDCK fail to provide sufficient mechanical stability, as normally ensured by E‐cadherin, thus delaying the jamming transition.