Under ALI condition, acute phase proteins, mostly pro‐inflammatory signaling proteins, are abnormally secreted in plasma.[27] Furthermore, massive intracellular proteins, which are leaked to plasma after cellular damage and further function as natural endogenous adjuvants to induce phlogosis,[39] and Un and TO, comparing to TC, could better capture such kind of extracellular signaling proteins. The gene discussed is KLK7; the disease is acute respiratory distress syndrome.