↑, upregulated; ↓, downregulated; (+), positive correlation; (-), negative correlation; SLE, systemic lupus erythematosus; PBMCs, peripheral blood mononuclear cells; SLEDAI, systemic lupus erythematosus disease activity index; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; anti-dsDNA, anti-double stranded DNA; LN, lupus nephritis; eGFR, estimated glomerular filtration rate; IL, interleukin; SIRT1, silent information regulator 1; IFN, interferon. This evidence concerns the gene SIRT1 and systemic lupus erythematosus.