Patients who have locoregionally advanced disease at diagnosis receive combined modality therapy with a platinum-based chemotherapy backbone; [5, 6] however, in 2006, cetuximab, a chimeric monoclonal antibody and an epidermal growth factor receptor (EGFR) inhibitor, was approved with radiation therapy for locoregionally advanced HNSCC. Here, EGFR is linked to head and neck squamous cell carcinoma.