Within TCGA who had HPV-positive cancers, none of the oropharyngeal (n = 22) and only one of the overall head and neck patients (n = 36) had the amplified EGFR gene region, whereas within the HPV-negative cohort, six oropharyngeal (n = 11, 54.5%) and 124 of the overall head and neck patients (n = 243, 51.0%) had the amplified EGFR gene region. Here, EGFR is linked to cancer.