CDR2 and choreatic disease: These were defined as the onset of chorea within 2 years of a diagnosis of active cancer, or a positive serum or CSF autoantibody with high predictive value for cancer [such as anti-neuronal nuclear antibodies type 1 and 2 (ANNA-1,2), anti-CASPR2, anti-CRMP5/CV2, anti-Hu, anti-Ri, anti-Yo, and anti-GAD65] [65].