TP53 and cancer: Along with universally common signaling pathways implicated in cancer, such as HIF-1alpha, p53, and AP1 pathways, we identified a unique set of genes that were upregulated only in the singular condition of the UOK262 cells incubated in both Gln and Asn and which were not upregulated under Gln or Asn incubation alone (Fig. 2a).