Besides, there was a significant elevation of mRNA levels for both NLRP3 and NLRP6 in cells preincubated with L. salivarius and ETEC K88 infectious time for them was 3 h or 6 h (Fig. 2 c, d), but the expression level of NLRP3 started to decline after 6 h infection while that of NLRP6 began to drop after 12 h infection (Fig. 2 c, d). The gene discussed is NLRP6; the disease is infection.