Evidence showed that activation of PPAR-γ receptors reduces inflammation and oxidative stress in various tissues, including the kidney, nervous system, and liver (36), Also it has been observed that the PPAR-γ agonist pioglitazone improved anti-oxidant capacity, and increases SOD and CAT enzymes production in a kidney ischemia-reperfusion model (37). The gene discussed is SOD1; the disease is medical procedure.